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Study Information
Study Attribute Value
CEBS Accession Number: 002-02094-0001-0000-8
Chemical Name: Disperse blue 7
CASRN: 3179-90-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 264454_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/22/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 380 0.362 7.60 26.0 0.000
Test Chemical Disperse blue 7 
 0.16      
 50 1044 623 0.597 12.46 26.0 64.890 
 0.5       
 10 209 272 1.301 27.20 26.0 259.607 
1.6       
 10 210 502 2.390 50.20 26.0 560.526
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 509 0.486 10.18 26.0 34.203
Mitomycin-C 
 0.005     
 10 209 268 1.282 26.80 26.0 254.319
Trend: 31.523        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/08/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1039 402 0.387 8.04 26.0 0.000
Test Chemical Disperse blue 7 
 0.05      
 50 1038 486 0.468 9.72 26.0 21.012 
 0.16      
 50 1040 540 0.519 10.80 26.0 34.199 
 0.5       
 50 1012 997 0.985 19.94 26.0 154.627 
1.6       
 10 209 574 2.746 57.40 26.0 609.831
Positive Control Mitomycin-C 
 0.0E-4    
 50 1022 519 0.508 10.38 26.0 31.252
Mitomycin-C 
 0.005     
 10 206 263 1.277 26.30 26.0 229.973
Trend: 30.391        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/22/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 396 0.378 7.92 26.0 0.000
Test Chemical Disperse blue 7 
 0.5       
 50 1047 501 0.479 10.02 26.0 26.757 
1.6       
 50 1046 517 0.494 10.34 26.0 30.930 
5         
 50 1048 543 0.518 10.86 26.0 37.252 
16         
 50 1047 1226 1.171 24.52 26.0 210.187
Positive Control Cyclophosphamide 
 0.1       
 50 1046 518 0.495 10.36 26.0 31.183
Cyclophosphamide 
 0.6       
 10 210 173 0.824 17.30 26.0 118.226
Trend: 21.362        
Probability: 0.000