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Study Information
Study Attribute Value
CEBS Accession Number: 002-02094-0002-0000-9
Chemical Name: Disperse blue 7
CASRN: 3179-90-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 264454_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 12/08/1988    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Disperse blue 7 
25         
 50 64 1.280 72.0 35 0.700 46.0 29 0.580 44.0 0 0.000 0.0 
50         
 50 54 1.080 62.0 30 0.600 48.0 24 0.480 34.0 0 0.000 0.0 
100         
 50 78 1.560 76.0 43 0.860 60.0 35 0.700 50.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 55 0.275 23.5 20 0.100 9.5 35 0.175 15.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 25 0.500 42.0 10 0.200 20.0 14 0.280 24.0 1 0.020 1.0
Trend: 12.651 10.898 9.360  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/10/1988    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Disperse blue 7 
1000         
 100 41 0.410 32.0 25 0.250 20.0 16 0.160 15.0 0 0.000 0.0 
1600         
 100 80 0.800 52.0 35 0.350 31.0 34 0.340 28.0 11 0.110 2.0 
3000         
 100 61 0.610 43.0 33 0.330 29.0 26 0.260 18.0 2 0.020 2.0
Positive Control: Cyclophosphamide 
5         
 200 29 0.145 8.0 4 0.020 2.0 14 0.070 6.0 11 0.055 2.0
Cyclophosphamide 
7.5       
 50 17 0.340 30.0 2 0.040 4.0 14 0.280 26.0 1 0.020 1.0
Trend: 9.606 7.368 5.896  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 11/10/1988    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Disperse blue 7 
100         
 50 65 1.300 78.0 29 0.580 44.0 36 0.720 50.0 0 0.000 0.0 
160         
 50 55 1.100 68.0 30 0.600 44.0 24 0.480 42.0 1 0.020 1.0 
300         
 50 76 1.520 86.0 41 0.820 46.0 35 0.700 56.0 0 0.000 0.0 
500         
 16 25 1.563 75.0 12 0.750 43.8 13 0.813 62.5 0 0.000 0.0 
1000         
 15 18 1.200 73.3 9 0.600 46.7 9 0.600 46.7 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 57 0.285 21.5 20 0.100 10.0 27 0.135 12.0 10 0.050 1.0
Mitomycin-C 
 0.25      
 50 26 0.520 38.0 12 0.240 22.0 14 0.280 26.0 0 0.000 0.0
Trend: 12.754 8.703 9.831  
Probability: 0.000 0.000 0.000