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Study Information
Study Attribute Value
CEBS Accession Number: 002-02102-0001-0000-8
Chemical Name: Doxylamine succinate
CASRN: 562-10-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 968948_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/03/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 392 0.373 7.84 26.0 0.000
Test Chemical Doxylamine succinate 
16         
 50 1048 397 0.379 7.94 26.0 1.469 
50         
 50 1050 409 0.390 8.18 26.0 4.337 
160         
 50 1048 383 0.365 7.66 26.0 -2.109 
500         
 50 1047 425 0.406 8.50 26.0 8.729 
1600         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 566 0.540 11.32 26.0 44.525
Mitomycin-C 
 0.005     
 10 209 318 1.522 31.80 26.0 307.553
Trend: 0.854        
Probability: 0.197        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/03/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 462 0.441 9.24 26.0 0.000
Test Chemical Doxylamine succinate 
160         
 50 1035 515 0.498 10.30 26.0 12.872 
500         
 50 1044 518 0.496 10.36 26.0 12.551 
1600         
 50 1048 562 0.536 11.24 26.0 21.645 
5000         
 50 1046 580 0.554 11.60 26.0 25.781
Positive Control Cyclophosphamide 
 0.1       
 50 1052 600 0.570 12.00 26.0 29.376
Cyclophosphamide 
 0.6       
 10 209 235 1.124 23.50 26.0 155.059
Trend: 3.832        
Probability: 0.000