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Study Information
Study Attribute Value
CEBS Accession Number: 002-02102-0002-0000-9
Chemical Name: Doxylamine succinate
CASRN: 562-10-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 968948_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 07/23/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0
Test Chemical: Doxylamine succinate 
1600         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
3000         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
5000         
 200 15 0.075 5.0 5 0.025 1.5 11 0.055 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 67 0.335 21.0 24 0.120 11.5 32 0.160 12.5 11 0.055 2.0
Mitomycin-C 
 0.25      
 50 46 0.920 46.0 20 0.400 24.0 26 0.520 32.0 0 0.000 0.0
Trend: 1.246 2.217 0.639  
Probability: 0.106 0.013 0.261  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/23/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0
Test Chemical: Doxylamine succinate 
1600         
 200 7 0.035 3.5 1 0.005 0.5 6 0.030 3.0 0 0.000 0.0 
3000         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0 
5000         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 41 0.205 18.5 13 0.065 6.0 28 0.140 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 36 0.720 46.0 10 0.200 16.0 26 0.520 42.0 0 0.000 0.0
Trend: -0.089 1.330 -0.401  
Probability: 0.535 0.092 0.656