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Study Information
Study Attribute Value
CEBS Accession Number: 002-02106-0001-0000-2
Chemical Name: Ellagic acid
CASRN: 476-66-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 417915_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/19/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1017 468 0.460 9.36 26.0 0.000
Test Chemical Ellagic acid 
2.17      
 50 1000 435 0.435 8.70 26.0 -5.471 
6.5       
 50 1026 433 0.422 8.66 26.0 -8.290 
21.7       
 50 1001 490 0.490 9.80 31.5 6.374 
65         
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1023 598 0.585 11.96 26.0 27.028
Mitomycin-C 
 0.01      
 5 104 145 1.394 29.00 26.0 202.977
Trend: 0.815        
Probability: 0.208        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/19/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1022 464 0.454 9.28 26.0 0.000
Test Chemical Ellagic acid 
6.5       
 50 1013 458 0.452 9.16 26.0 -0.416 
21.7       
 50 1014 475 0.468 9.50 26.0 3.178 
65         
 50 1021 556 0.545 11.12 26.0 19.945 
217         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1024 691 0.675 13.82 26.0 48.632
Cyclophosphamide 
2         
 5 105 149 1.419 29.80 26.0 212.557
Trend: 2.939        
Probability: 0.002        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/27/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1017 411 0.404 8.22 26.0 0.000
Test Chemical Ellagic acid 
64.3       
 50 1021 510 0.500 10.20 26.0 23.601 
130.5       
 50 1024 552 0.539 11.04 26.0 33.388 
195         
 50 1013 581 0.574 11.62 31.5 41.921 
261         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1007 588 0.584 11.76 26.0 44.486
Cyclophosphamide 
2         
 5 104 174 1.673 34.80 26.0 313.995
Trend: 5.456        
Probability: 0.000