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Study Information
Study Attribute Value
CEBS Accession Number: 002-02106-0002-0000-3
Chemical Name: Ellagic acid
CASRN: 476-66-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 417915_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Negative 
No Activation  3  Positive 

Trial #:1   Activation: No Activation    Date: 03/11/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Medium 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Ellagic acid 
60         
 200 13 0.065 4.5 0 0.000 0.0 13 0.065 4.5 0 0.000 0.0 
79.5       
 200 36 0.180 10.5 0 0.000 0.0 36 0.180 10.5 0 0.000 0.0 
100         
 10 39 3.900 100.0 16 1.600 80.0 23 2.300 80.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 56 0.280 15.5 30 0.150 10.5 26 0.130 8.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 12 0.480 32.0 4 0.160 16.0 8 0.320 20.0 0 0.000 0.0
Trend: 6.914 6.206 6.359  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/11/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Medium 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ellagic acid 
50         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
100         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
150         
 200 14 0.070 4.0 1 0.005 0.5 13 0.065 4.0 0 0.000 0.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 17 0.085 8.5 4 0.020 2.0 13 0.065 6.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 10 0.400 28.0 4 0.160 16.0 6 0.240 20.0 0 0.000 0.0
Trend: 2.493 0.097 2.938  
Probability: 0.006 0.461 0.002  


Trial #:2   Activation: No Activation    Date: 03/26/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Medium 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ellagic acid 
60         
 200 10 0.050 4.0 1 0.005 0.5 9 0.045 4.0 0 0.000 0.0 
70.2       
 200 10 0.050 5.0 4 0.020 2.0 6 0.030 3.0 0 0.000 0.0 
80         
 200 13 0.065 6.0 9 0.045 4.0 4 0.020 2.0 0 0.000 0.0 
90         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 18 0.090 7.0 11 0.055 4.5 7 0.035 3.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 14 0.560 40.0 5 0.200 20.0 9 0.360 32.0 0 0.000 0.0
Trend: 2.858 2.893 1.046  
Probability: 0.002 0.002 0.148  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/16/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Ellagic acid 
150         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
200         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
250         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 24 0.120 11.5 8 0.040 4.0 16 0.080 7.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 13 0.520 36.0 7 0.280 24.0 6 0.240 20.0 0 0.000 0.0
Trend: -0.907 -0.749 -0.627  
Probability: 0.818 0.773 0.735  


Trial #:3   Activation: No Activation    Date: 04/30/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Ellagic acid 
70.2       
 100 18 0.180 7.0 0 0.000 0.0 18 0.180 7.0 0 0.000 0.0 
80         
 100 17 0.170 11.0 2 0.020 2.0 15 0.150 10.0 0 0.000 0.0 
90         
 100 19 0.190 15.0 1 0.010 1.0 18 0.180 14.0 0 0.000 0.0 
100         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 36 0.360 22.0 15 0.150 12.0 21 0.210 14.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 33 1.320 68.0 16 0.640 48.0 17 0.680 44.0 0 0.000 0.0
Trend: 3.400 1.323 3.164  
Probability: 0.000 0.093 0.001