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Study Information
Study Attribute Value
CEBS Accession Number: 002-02109-0001-0000-5
Chemical Name: Emodin
CASRN: 518-82-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: A00749_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 12/05/1991    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Emodin 
10         
 200 13 0.065 5.5 3 0.015 1.0 10 0.050 5.0 0 0.000 0.0 
15         
 200 25 0.125 11.5 13 0.065 6.5 12 0.060 5.5 0 0.000 0.0 
20         
 50 17 0.340 32.0 11 0.220 20.0 6 0.120 12.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 16 0.640 32.0 5 0.200 12.0 11 0.440 24.0 0 0.000 0.0
Trend: 6.240 5.450 3.219  
Probability: 0.000 0.000 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/05/1991    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Emodin 
100         
 200 14 0.070 3.5 7 0.035 1.5 7 0.035 2.5 0 0.000 0.0 
150         
 200 7 0.035 3.0 1 0.005 0.5 6 0.030 2.5 0 0.000 0.0 
200         
 200 31 0.155 12.5 10 0.050 4.5 21 0.105 8.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 6 0.240 20.0 3 0.120 8.0 2 0.080 8.0 1 0.040 4.0
Trend: 4.745 2.503 3.995  
Probability: 0.000 0.006 0.000