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Study Information
Study Attribute Value
CEBS Accession Number: 002-02113-0008-0000-7
Chemical Name: Endosulfan
CASRN: 115-29-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 309806
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Acetone 
 0         
 91 99 105 38 31
    85 91 75 29
    102 116 73 24
    94 94 90 32
Test Chemical Endosulfan 
3.125     
 70 79 81 38 34
    97 91 84 29
  
6.25      
 83 90 98 40 38
    82 90 90 37
  
12.5       
 70 60 87 42 40
    92 79 105 38
  
25         
 30 4 2997 3367 2857*
    39 5 2711 2347
  
50         
   
Positive Control Methyl Methane Sulfonate 
15         
 49 32 169 115 103*
    75 38 205 92
Methyl Methane Sulfonate 
250         
 81 86 530 219 234*
    67 76 498 248

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Acetone 
 0         
 96 102 138 48 55
    94 104 136 48
    62 95 126 68
    74 99 123 56
Test Chemical Endosulfan 
9.3       
 88 90 134 51 54
    84 96 145 58
  
14         
 71 66 153 72 63
    87 19 140 53
  
18.6       
 88 58 240 91 92*
    91 52 257 94
  
23.3       
 60 14 623 347 299*
    66 18 500 251
  
28         
 39r 5 1544 1331
    38 4 1112 971
Positive Control Methyl Methane Sulfonate 
15         
 39 23 314 267 264*
    58 39 451 261
Methyl Methane Sulfonate 
250         
 69 68 560 271 287*
    68 63 613 303

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination