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Study Information
Study Attribute Value
CEBS Accession Number: 002-02116-0001-0000-3
Chemical Name: Ephedrine sulfate
CASRN: 134-72-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 627991_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/10/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1036 428 0.413 8.56 25.8 0.000
Test Chemical Ephedrine sulfate 
166.8       
 50 1033 427 0.413 8.54 25.8 0.056 
500.3       
 50 1041 395 0.379 7.90 25.8 -8.154 
1700         
 50 1039 556 0.535 11.12 31.0 29.531 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1035 623 0.602 12.46 25.8 45.701
Mitomycin-C 
 0.01      
 5 106 250 2.358 50.00 25.8 470.887
Trend: 3.726        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/23/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1019 424 0.416 8.48 25.6 19.482
Medium 
0         
 50 1028 358 0.348 7.16 25.6 0.000
Test Chemical Ephedrine sulfate 
1000         
 50 1014 401 0.395 8.02 25.6 13.558 
1250         
 50 1029 409 0.397 8.18 25.6 14.135 
1490         
 50 1022 480 0.470 9.60 31.3 34.865 
1740         
 0 0 0 0.000 0.00 31.3 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1019 591 0.580 11.82 25.6 66.542
Mitomycin-C 
 0.01      
 5 103 190 1.845 38.00 25.6 429.696
Trend: 4.063        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/10/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1035 503 0.486 10.06 25.7 0.000
Test Chemical Ephedrine sulfate 
5000         
 50 1020 505 0.495 10.10 25.7 1.874
Positive Control Cyclophosphamide 
2         
 5 102 184 1.804 36.80 25.7 271.185
Trend: 0.000        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/23/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1032 473 0.458 9.46 26.6 3.276
Medium 
0         
 50 1023 454 0.444 9.08 26.6 0.000
Test Chemical Ephedrine sulfate 
6500         
 50 1011 537 0.531 10.74 26.6 19.686 
7000         
 50 1033 516 0.500 10.32 26.6 12.556 
7500         
 50 1029 525 0.510 10.50 31.2 14.964 
8000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1035 625 0.604 12.50 26.6 36.069
Cyclophosphamide 
2         
 5 101 186 1.842 37.20 26.6 314.965
Trend: 1.685        
Probability: 0.046