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Study Information
Study Attribute Value
CEBS Accession Number: 002-02116-0002-0000-4
Chemical Name: Ephedrine sulfate
CASRN: 134-72-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 627991_CA
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Test Failure 

Trial #:1   Activation: No Activation    Date: 06/08/1983    Harvest Time: 20.8 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Medium
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Ephedrine sulfate
1490         
100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
1740         
100 7 0.070 7.0 5 0.050 5.0 2 0.020 2.0 0 0.000 0.0
1990         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
2490         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
2760         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
3000         
100 5 0.050 3.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0
Positive Control: Mitomycin-C
 0.05      
50 41 0.820 50.0 25 0.500 38.0 16 0.320 24.0 0 0.000 0.0
Trend: -0.638 -0.473 0.025  
Probability: 0.738 0.682 0.490  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/08/1983    Harvest Time: 20.8 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Medium
0         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ephedrine sulfate
5600         
200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
6000         
100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0
6400         
200 19 0.095 5.5 6 0.030 2.5 13 0.065 4.0 0 0.000 0.0
7000         
200 28 0.140 4.5 16 0.080 4.0 12 0.060 3.5 0 0.000 0.0
7600         
100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
8000         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide
10         
50 13 0.260 20.0 7 0.140 12.0 6 0.120 8.0 0 0.000 0.0
Trend: 1.861 1.541 1.964  
Probability: 0.031 0.062 0.025