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Study Information
Study Attribute Value
CEBS Accession Number: 002-02116-0002-0000-4
Chemical Name: Ephedrine sulfate
CASRN: 134-72-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 627991_CA
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Test Failure 

Trial #:1   Activation: No Activation    Date: 06/08/1983    Harvest Time: 20.8 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Ephedrine sulfate 
1490         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
1740         
 100 7 0.070 7.0 5 0.050 5.0 2 0.020 2.0 0 0.000 0.0 
1990         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
2490         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
2760         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
3000         
 100 5 0.050 3.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.05      
 50 41 0.820 50.0 25 0.500 38.0 16 0.320 24.0 0 0.000 0.0
Trend: -0.638 -0.473 0.025  
Probability: 0.738 0.682 0.490  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/08/1983    Harvest Time: 20.8 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ephedrine sulfate 
5600         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
6000         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
6400         
 200 19 0.095 5.5 6 0.030 2.5 13 0.065 4.0 0 0.000 0.0 
7000         
 200 28 0.140 4.5 16 0.080 4.0 12 0.060 3.5 0 0.000 0.0 
7600         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
8000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 13 0.260 20.0 7 0.140 12.0 6 0.120 8.0 0 0.000 0.0
Trend: 1.861 1.541 1.964  
Probability: 0.031 0.062 0.025