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Study Information
Study Attribute Value
CEBS Accession Number: 002-02116-0003-0000-5
Chemical Name: Ephedrine sulfate
CASRN: 134-72-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 932450_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/31/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 393 0.375 7.86 31.0 1.028
Water 
0         
 50 1049 389 0.371 7.78 26.0 0.000
Test Chemical Ephedrine sulfate 
50         
 50 1049 427 0.407 8.54 26.0 9.769 
167         
 50 1048 393 0.375 7.86 26.0 1.125 
500         
 50 1046 406 0.388 8.12 31.0 4.670 
1667         
 0 0 0 0.000 0.00 31.0 N/A 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 534 0.509 10.68 26.0 37.275
Mitomycin-C 
 0.004     
 10 210 275 1.310 27.50 26.0 253.134
Trend: 0.220        
Probability: 0.413        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/31/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1042 422 0.405 8.44 26.0 0.000
Test Chemical Ephedrine sulfate 
500         
 50 1048 415 0.396 8.30 26.0 -2.222 
1667         
 50 1050 410 0.390 8.20 26.0 -3.584 
5000         
 50 1047 456 0.436 9.12 26.0 7.541
Positive Control Cyclophosphamide 
 0.125     
 50 1048 613 0.585 12.26 26.0 44.429
Cyclophosphamide 
 0.5       
 10 210 196 0.933 19.60 26.0 130.458
Trend: 0.956        
Probability: 0.170