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Study Information
Study Attribute Value
CEBS Accession Number: 002-02118-0001-0000-5
Chemical Name: Epichlorhydrin
CASRN: 106-89-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 099989_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/02/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 392 0.376 7.84 26.0 0.000
Negative (Not Specified) 
0         
 50 1051 399 0.380 7.98 26.0 1.011
Test Chemical Epichlorhydrin 
 0.5       
 50 1048 536 0.511 10.72 26.0 36.082 
1.7       
 50 1047 740 0.707 14.80 26.0 88.054 
5         
 50 1050 1350 1.286 27.00 26.0 242.092 
17         
 50 1053 2886 2.741 57.72 26.0 629.233 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 677 0.648 13.54 26.0 72.374
Mitomycin-C 
 0.005     
 10 212 277 1.307 27.70 26.0 247.650
Trend: 53.217        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/13/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 362 0.345 7.24 26.0 -15.984
Dimethyl Sulfoxide 
0         
 50 1043 428 0.410 8.56 26.0 0.000
Test Chemical Epichlorhydrin 
 0.5       
 50 1049 446 0.425 8.92 26.0 3.610 
1.7       
 50 1049 593 0.565 11.86 26.0 37.759 
5         
 50 1050 965 0.919 19.30 26.0 123.964 
17         
 50 1052 1744 1.658 34.88 31.0 303.991 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1043 591 0.567 11.82 26.0 38.084
Mitomycin-C 
 0.005     
 10 209 279 1.335 27.90 26.0 225.311
Trend: 34.344        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/02/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 407 0.391 8.14 26.0 0.000
Negative (Not Specified) 
0         
 50 1049 437 0.417 8.74 26.0 6.655
Test Chemical Epichlorhydrin 
5         
 50 1050 437 0.416 8.74 26.0 6.553 
17         
 50 1049 481 0.459 9.62 26.0 17.393 
50         
 50 1049 663 0.632 13.26 26.0 61.812 
167         
 50 1042 2199 2.110 43.98 26.0 440.295 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1043 556 0.533 11.12 26.0 36.478
Cyclophosphamide 
 0.5       
 10 208 170 0.817 17.00 26.0 109.247
Trend: 41.762        
Probability: 0.000