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Study Information
Study Attribute Value
CEBS Accession Number: 002-02118-0002-0000-6
Chemical Name: Epichlorhydrin
CASRN: 106-89-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 099989_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 03/02/1989    Harvest Time: 16 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Epichlorhydrin 
9.4       
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
20         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0 
43         
 200 16 0.080 8.0 3 0.015 1.5 13 0.065 6.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 200 43 0.215 16.5 24 0.120 11.0 19 0.095 8.0 0 0.000 0.0
Mitomycin-C 
 0.4       
 50 25 0.500 34.0 15 0.300 24.0 10 0.200 14.0 0 0.000 0.0
Trend: 4.454 1.270 4.591  
Probability: 0.000 0.102 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/02/1989    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Epichlorhydrin 
43         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
93         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
200         
 200 34 0.170 13.5 16 0.080 8.0 18 0.090 6.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 27 0.135 12.5 9 0.045 4.5 18 0.090 9.0 0 0.000 0.0
Cyclophosphamide 
15         
 50 36 0.720 26.0 17 0.340 22.0 9 0.180 10.0 10 0.200 2.0
Trend: 5.798 4.928 3.621  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 03/24/1989    Harvest Time: 16 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Epichlorhydrin 
50         
 50 3 0.060 6.0 1 0.020 2.0 2 0.040 4.0 0 0.000 0.0 
60         
 50 9 0.180 14.0 4 0.080 8.0 5 0.100 8.0 0 0.000 0.0 
75         
 50 13 0.260 20.0 1 0.020 2.0 12 0.240 20.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 200 53 0.265 18.5 29 0.145 13.0 14 0.070 6.5 10 0.050 0.5
Mitomycin-C 
 0.4       
 50 21 0.420 36.0 15 0.300 26.0 6 0.120 12.0 0 0.000 0.0
Trend: 4.589 1.619 4.644  
Probability: 0.000 0.053 0.000