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Study Information
Study Attribute Value
CEBS Accession Number: 002-02119-0001-0000-6
Chemical Name: Epinephrine
CASRN: 51-43-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 784620_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/25/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 438 0.422 8.76 26.0 0.000
Test Chemical Epinephrine 
 0.5       
 50 1048 477 0.455 9.54 26.0 7.761 
1.6       
 50 1050 446 0.425 8.92 26.0 0.566 
5         
 50 1046 447 0.427 8.94 26.0 1.177 
10         
 50 1050 528 0.503 10.56 26.0 19.055
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 537 0.512 10.74 26.0 21.316
Mitomycin-C 
 0.005     
 10 210 273 1.300 27.30 26.0 207.785
Trend: 1.833        
Probability: 0.033        

Trial #: 2    Activation: No Activation    Date: 11/11/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 399 0.380 7.98 26.0 0.000
Test Chemical Epinephrine 
3         
 50 1049 419 0.399 8.38 26.0 5.213 
5         
 50 1050 435 0.414 8.70 26.0 9.126 
7.5       
 50 1050 413 0.393 8.26 26.0 3.607 
10         
 50 1050 480 0.457 9.60 26.0 20.415
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 503 0.482 10.06 26.0 27.032
Mitomycin-C 
 0.005     
 10 210 265 1.262 26.50 26.0 232.396
Trend: 2.268        
Probability: 0.012        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/25/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 454 0.433 9.08 26.0 0.000
Test Chemical Epinephrine 
 0.5       
 50 1045 457 0.437 9.14 26.0 0.950 
1.6       
 50 1042 462 0.443 9.24 26.0 2.348 
5         
 50 1045 481 0.460 9.62 26.0 6.251 
10         
 50 1050 431 0.410 8.62 26.0 -5.247
Positive Control Cyclophosphamide 
 0.1       
 50 1050 592 0.564 11.84 26.0 30.148
Cyclophosphamide 
 0.6       
 10 210 244 1.162 24.40 26.0 168.211
Trend: -0.217        
Probability: 0.586