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Study Information
Study Attribute Value
CEBS Accession Number: 002-02131-0002-0000-1
Chemical Name: Ethionamide
CASRN: 536-33-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 457178_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 07/01/1988    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Ethionamide 
800         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
1000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
1200         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 30 0.150 14.0 8 0.040 4.0 22 0.110 10.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 25 0.500 38.0 5 0.100 8.0 20 0.400 34.0 0 0.000 0.0
Trend: -1.572 -0.658 -1.432  
Probability: 0.942 0.745 0.924  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/09/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 2.0 1 0.005 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Ethionamide 
500         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
1000         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
1600         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 31 0.155 15.0 6 0.030 3.0 25 0.125 12.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 15 0.300 28.0 3 0.060 6.0 12 0.240 24.0 0 0.000 0.0
Trend: -0.862 -0.084 0.000  
Probability: 0.806 0.534 0.500  


Trial #:2   Activation: No Activation    Date: 02/27/1986    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ethionamide 
160         
 200 2 0.010 1.0 1 0.005 10.5 1 0.005 0.5 0 0.000 0.0 
300         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
500         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
1000         
 65 3 0.046 4.6 2 0.031 3.1 1 0.015 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 46 0.230 21.0 17 0.085 8.0 29 0.145 13.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 24 0.480 34.0 7 0.140 10.0 17 0.340 28.0 0 0.000 0.0
Trend: 2.348 -1.582 1.583  
Probability: 0.009 0.943 0.057