Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02132-0004-0000-4 |
Chemical Name: | Ethoxylated dodecyl alcohol |
CASRN: | 9002-92-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 487120_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ethoxylated dodecyl alcohol | 16 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
30 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
50 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 33 | 0.165 | 15.0 | 15 | 0.075 | 7.0 | 18 | 0.090 | 8.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 25 | 0.500 | 28.0 | 8 | 0.160 | 14.0 | 7 | 0.140 | 14.0 | 10 | 0.200 | 1.0 | |
Trend: | -0.443 | 0.000 | -0.443 | ||||||||||||
Probability: | 0.671 | 0.000 | 0.671 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 0 | 2 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Ethoxylated dodecyl alcohol | 5 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
10 | 200 | 5 | 0.025 | 2.5 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
16 | 200 | 8 | 0.040 | 3.5 | 1 | 0.005 | 0.5 | 7 | 0.035 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 45 | 0.225 | 19.0 | 15 | 0.075 | 7.5 | 30 | 0.150 | 13.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 20 | 0.400 | 30.0 | 4 | 0.080 | 8.0 | 16 | 0.320 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.855 | 1.485 | 1.288 | ||||||||||||
Probability: | 0.032 | 0.069 | 0.099 |