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Study Information
Study Attribute Value
CEBS Accession Number: 002-02133-0001-0000-2
Chemical Name: Ethoxyquin
CASRN: 91-53-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 247323_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/07/1991    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 359 0.342 7.18 26.0 -5.931
Dimethyl Sulfoxide 
0         
 50 1050 382 0.364 7.64 26.0 0.000
Test Chemical Ethoxyquin 
1.7       
 50 1048 442 0.422 8.84 26.0 15.928 
5         
 50 1050 458 0.436 9.16 26.0 19.895 
17         
 50 1048 472 0.450 9.44 26.0 23.796 
50         
 0 0 0 0.000 0.00 31.0 N/A 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 515 0.490 10.30 26.0 34.688
Mitomycin-C 
 0.004     
 10 212 212 1.000 21.20 26.0 174.869
Trend: 3.126        
Probability: 0.001        

Trial #: 2    Activation: No Activation    Date: 04/24/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 370 0.352 7.40 26.0 0.000
Negative (Not Specified) 
0         
 50 1050 343 0.327 6.86 26.0 -7.297
Test Chemical Ethoxyquin 
7.5       
 50 1051 447 0.425 8.94 26.0 20.696 
15         
 50 1049 461 0.439 9.22 26.0 24.713 
30         
 50 1049 469 0.447 9.38 26.0 26.878
Positive Control Mitomycin-C 
 0.001     
 50 1050 546 0.520 10.92 26.0 47.568
Mitomycin-C 
 0.004     
 10 209 268 1.282 26.80 26.0 263.895
Trend: 3.350        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/07/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 379 0.361 7.58 26.0 0.000
Negative (Not Specified) 
0         
 50 1050 399 0.380 7.98 31.0 5.277
Test Chemical Ethoxyquin 
17         
 50 1049 378 0.360 7.56 26.0 -0.169 
50         
 50 1049 406 0.387 8.12 26.0 7.226 
167         
 50 1041 457 0.439 9.14 31.0 21.623 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1051 598 0.569 11.96 26.0 57.634
Cyclophosphamide 
 0.5       
 10 209 181 0.866 18.10 26.0 139.929
Trend: 3.049        
Probability: 0.001