Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02133-0001-0000-2 |
Chemical Name: | Ethoxyquin |
CASRN: | 91-53-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 247323_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1049 | 359 | 0.342 | 7.18 | 26.0 | -5.931 |
Dimethyl Sulfoxide | 0 | 50 | 1050 | 382 | 0.364 | 7.64 | 26.0 | 0.000 | |
Test Chemical | Ethoxyquin | 1.7 | 50 | 1048 | 442 | 0.422 | 8.84 | 26.0 | 15.928 |
5 | 50 | 1050 | 458 | 0.436 | 9.16 | 26.0 | 19.895 | ||
17 | 50 | 1048 | 472 | 0.450 | 9.44 | 26.0 | 23.796 | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 31.0 | N/A | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1051 | 515 | 0.490 | 10.30 | 26.0 | 34.688 |
Mitomycin-C | 0.004 | 10 | 212 | 212 | 1.000 | 21.20 | 26.0 | 174.869 | |
Trend: | 3.126 | ||||||||
Probability: | 0.001 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 370 | 0.352 | 7.40 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1050 | 343 | 0.327 | 6.86 | 26.0 | -7.297 | |
Test Chemical | Ethoxyquin | 7.5 | 50 | 1051 | 447 | 0.425 | 8.94 | 26.0 | 20.696 |
15 | 50 | 1049 | 461 | 0.439 | 9.22 | 26.0 | 24.713 | ||
30 | 50 | 1049 | 469 | 0.447 | 9.38 | 26.0 | 26.878 | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1050 | 546 | 0.520 | 10.92 | 26.0 | 47.568 |
Mitomycin-C | 0.004 | 10 | 209 | 268 | 1.282 | 26.80 | 26.0 | 263.895 | |
Trend: | 3.350 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 379 | 0.361 | 7.58 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1050 | 399 | 0.380 | 7.98 | 31.0 | 5.277 | |
Test Chemical | Ethoxyquin | 17 | 50 | 1049 | 378 | 0.360 | 7.56 | 26.0 | -0.169 |
50 | 50 | 1049 | 406 | 0.387 | 8.12 | 26.0 | 7.226 | ||
167 | 50 | 1041 | 457 | 0.439 | 9.14 | 31.0 | 21.623 | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.125 | 50 | 1051 | 598 | 0.569 | 11.96 | 26.0 | 57.634 |
Cyclophosphamide | 0.5 | 10 | 209 | 181 | 0.866 | 18.10 | 26.0 | 139.929 | |
Trend: | 3.049 | ||||||||
Probability: | 0.001 |