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Study Information
Study Attribute Value
CEBS Accession Number: 002-02136-0001-0000-5
Chemical Name: Ethyl acetate
CASRN: 141-78-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 390219_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/02/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 496 0.479 9.92 26.5 0.000
Test Chemical Ethyl acetate 
151         
 50 1051 452 0.430 9.04 26.5 -10.258 
500         
 50 1036 456 0.440 9.12 26.5 -8.153 
1510         
 50 1035 486 0.470 9.72 26.5 -2.016 
5020         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 646 0.617 12.92 26.5 28.749
Mitomycin-C 
 0.01      
 10 207 764 3.691 76.40 26.5 670.161
Trend: -0.216        
Probability: 0.585        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/02/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1030 526 0.511 10.52 25.5 -4.224
Dimethyl Sulfoxide 
0         
 50 1024 546 0.533 10.92 25.5 0.000
Test Chemical Ethyl acetate 
500         
 50 1047 540 0.516 10.80 25.5 -3.272 
1510         
 50 1029 524 0.509 10.48 25.5 -4.496 
5020         
 50 1029 648 0.630 12.96 25.5 18.105
Positive Control Cyclophosphamide 
 0.5       
 50 1024 730 0.713 14.60 25.5 33.700
Cyclophosphamide 
2.5       
 10 210 388 1.848 38.80 25.5 246.513
Trend: 2.793        
Probability: 0.003        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 420 0.401 8.40 26.0 0.000
Test Chemical Ethyl acetate 
1010         
 50 1043 447 0.429 8.94 26.0 6.837 
4020         
 50 1029 514 0.500 10.28 26.0 24.522 
5020         
 50 1037 568 0.548 11.36 26.0 36.542
Positive Control Cyclophosphamide 
 0.5       
 50 1038 642 0.618 12.84 26.0 54.182
Cyclophosphamide 
2.5       
 10 206 291 1.413 29.10 26.0 252.146
Trend: 5.282        
Probability: 0.000