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Study Information
Study Attribute Value
CEBS Accession Number: 002-02136-0002-0000-6
Chemical Name: Ethyl acetate
CASRN: 141-78-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 390219_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/29/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ethyl acetate 
500         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
1510         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
5010         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.75      
 200 101 0.505 29.0 26 0.130 9.5 75 0.375 24.5 0 0.000 0.0
Mitomycin-C 
5         
 50 60 1.200 68.0 8 0.160 16.0 51 1.020 64.0 1 0.020 1.0
Trend: -0.008 0.000 -0.008  
Probability: 0.503 0.000 0.503  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/11/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Ethyl acetate 
3010         
 200 11 0.055 4.0 1 0.005 0.5 9 0.045 3.5 1 0.005 1.0 
4020         
 200 7 0.035 3.5 5 0.025 2.5 2 0.010 1.0 0 0.000 0.0 
5020         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 43 0.860 36.0 13 0.260 22.0 10 0.200 18.0 20 0.400 2.0
Trend: -0.638 0.750 -1.397  
Probability: 0.738 0.227 0.919  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/28/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Ethyl acetate 
500         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
1510         
 200 2 0.010 0.5 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
5010         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 25 173 6.920 96.0 24 0.960 36.0 17 0.680 28.0 132 5.280 15.0
Trend: 0.008 1.259 -0.600  
Probability: 0.497 0.104 0.726