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Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0001-0000-6
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 402439_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 04/16/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 314 0.300 6.28 26.5 0.000
Test Chemical Ethyl acrylate 
 0.5       
 50 1050 285 0.271 5.70 26.5 -9.581 
1.5       
 50 1050 312 0.297 6.24 26.5 -1.015 
5         
 50 1051 359 0.342 7.18 26.5 13.787 
15         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1045 513 0.491 10.26 26.5 63.532
Mitomycin-C 
 0.01      
 10 209 217 1.038 21.70 26.5 245.872
Trend: 2.000        
Probability: 0.023        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/16/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 333 0.318 6.66 26.0 0.000
Test Chemical Ethyl acrylate 
15         
 50 1044 343 0.329 6.86 26.0 3.299 
50         
 50 1046 371 0.355 7.42 30.0 11.518 
150         
 50 1055 467 0.443 9.34 26.0 39.177 
500         
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1048 818 0.781 16.36 26.0 145.411
Cyclophosphamide 
2.5       
 10 210 433 2.062 43.30 26.0 548.293
Trend: 4.793        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/23/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 443 0.426 8.86 26.0 0.000
Test Chemical Ethyl acrylate 
51.5       
 50 1034 436 0.422 8.72 26.0 -0.914 
103         
 50 1024 498 0.486 9.96 26.0 14.282 
155         
 50 1024 552 0.539 11.04 26.0 26.674 
206         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1036 564 0.544 11.28 26.0 27.928
Cyclophosphamide 
2.5       
 10 204 215 1.054 21.50 26.0 147.660
Trend: 4.280        
Probability: 0.000