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Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0001-0000-6
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 402439_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 04/16/1985    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1046 314 0.300 6.28 26.5 0.000
Test Chemical Ethyl acrylate
 0.5       
50 1050 285 0.271 5.70 26.5 -9.581
1.5       
50 1050 312 0.297 6.24 26.5 -1.015
5         
50 1051 359 0.342 7.18 26.5 13.787
15         
0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C
 0.0015    
50 1045 513 0.491 10.26 26.5 63.532
Mitomycin-C
 0.01      
10 209 217 1.038 21.70 26.5 245.872
Trend: 2.000        
Probability: 0.023        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/16/1985    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1047 333 0.318 6.66 26.0 0.000
Test Chemical Ethyl acrylate
15         
50 1044 343 0.329 6.86 26.0 3.299
50         
50 1046 371 0.355 7.42 30.0 11.518
150         
50 1055 467 0.443 9.34 26.0 39.177
500         
0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide
 0.4       
50 1048 818 0.781 16.36 26.0 145.411
Cyclophosphamide
2.5       
10 210 433 2.062 43.30 26.0 548.293
Trend: 4.793        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/23/1986    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1041 443 0.426 8.86 26.0 0.000
Test Chemical Ethyl acrylate
51.5       
50 1034 436 0.422 8.72 26.0 -0.914
103         
50 1024 498 0.486 9.96 26.0 14.282
155         
50 1024 552 0.539 11.04 26.0 26.674
206         
0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide
 0.5       
50 1036 564 0.544 11.28 26.0 27.928
Cyclophosphamide
2.5       
10 204 215 1.054 21.50 26.0 147.660
Trend: 4.280        
Probability: 0.000