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Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0002-0000-7
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 402439_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 05/30/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0
Test Chemical: Ethyl acrylate 
2.99      
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
9.95      
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
29.9       
 100 10 0.100 8.0 0 0.000 0.0 10 0.100 8.0 0 0.000 0.0 
49.8       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 30 0.300 22.0 11 0.110 10.0 19 0.190 16.0 0 0.000 0.0
Mitomycin-C 
5         
 50 34 0.680 38.0 10 0.200 20.0 24 0.480 30.0 0 0.000 0.0
Trend: 2.408 0.000 2.408  
Probability: 0.008 0.000 0.008  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/23/1986    Harvest Time: 21.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Ethyl acrylate 
103         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
155         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
309         
 50 158 3.160 68.0 37 0.740 36.0 30 0.600 32.0 91 1.820 10.0
Positive Control: Cyclophosphamide 
50         
 50 33 0.660 40.0 18 0.360 30.0 14 0.280 18.0 1 0.020 1.0
Trend: 11.265 8.330 7.329  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 05/30/1985    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: Ethyl acrylate 
29.9       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
99.5       
 200 7 0.035 3.0 3 0.015 1.5 4 0.020 1.5 0 0.000 0.0 
150         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
299         
 165 19 0.115 10.3 4 0.024 2.4 15 0.091 8.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 27 0.540 42.0 12 0.240 20.0 15 0.300 26.0 0 0.000 0.0
Trend: 3.370 2.169 2.837  
Probability: 0.000 0.015 0.002