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Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0003-0000-8
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 550589_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 02/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 359 0.342 7.18 26.0 0.000
Test Chemical Ethyl acrylate 
 0.5       
 50 1051 373 0.355 7.46 26.0 3.702 
1.6       
 50 1048 434 0.414 8.68 26.0 21.007 
5         
 50 1049 431 0.411 8.62 26.0 20.056 
16         
 50 1050 465 0.443 9.30 26.0 29.403
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 506 0.483 10.12 26.0 41.082
Mitomycin-C 
 0.005     
 10 210 333 1.586 33.30 26.0 363.347
Trend: 4.207        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/13/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 351 0.336 7.02 26.5 0.000
Test Chemical Ethyl acrylate 
3         
 50 1043 422 0.405 8.44 26.5 20.574 
5         
 50 1048 418 0.399 8.36 26.5 18.861 
10         
 50 1046 431 0.412 8.62 26.5 22.792 
16         
 50 1047 600 0.573 12.00 26.5 70.777 
25         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 568 0.542 11.36 26.5 61.515
Mitomycin-C 
 0.005     
 10 210 344 1.638 34.40 26.5 388.162
Trend: 7.452        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/01/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1042 457 0.439 9.14 26.0 0.000
Test Chemical Ethyl acrylate 
5         
 50 1050 501 0.477 10.02 26.0 8.793 
16         
 50 1046 464 0.444 9.28 26.0 1.143 
50         
 50 1047 528 0.504 10.56 26.0 14.984 
160         
 50 1047 551 0.526 11.02 26.0 19.993
Positive Control Cyclophosphamide 
 0.15      
 50 1049 622 0.593 12.44 26.0 35.197
Cyclophosphamide 
 0.6       
 10 210 235 1.119 23.50 26.0 155.153
Trend: 2.990        
Probability: 0.001