COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0004-0000-9
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 550589_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 04/02/1986    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ethyl acrylate 
16         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
30         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
50         
 200 139 0.695 39.5 20 0.100 9.0 119 0.595 36.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 44 0.220 18.5 18 0.090 8.0 26 0.130 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 35 0.700 44.0 9 0.180 18.0 16 0.320 28.0 10 0.200 1.0
Trend: 11.199 4.712 11.080  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/02/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 6 0.030 1.5 1 0.005 0.5 5 0.025 1.0 0 0.000 0.0
Test Chemical: Ethyl acrylate 
50         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
100         
 200 6 0.030 2.5 0 0.000 0.0 6 0.030 2.5 0 0.000 0.0 
160         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 24 0.120 12.0 7 0.035 3.5 17 0.085 8.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 14 0.280 24.0 9 0.180 16.0 5 0.100 8.0 0 0.000 0.0
Trend: 0.042 -1.356 0.397  
Probability: 0.483 0.912 0.346  


Trial #:2   Activation: No Activation    Date: 04/22/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ethyl acrylate 
10         
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0 
16         
 200 8 0.040 4.0 0 0.000 0.0 8 0.040 4.0 0 0.000 0.0 
30         
 200 12 0.060 6.0 0 0.000 0.0 12 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 51 0.255 21.0 17 0.085 8.0 34 0.170 15.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 18 0.360 36.0 8 0.160 16.0 10 0.200 20.0 0 0.000 0.0
Trend: 2.938 0.000 2.938  
Probability: 0.002 0.000 0.002