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Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0004-0000-9
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 550589_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 04/02/1986    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ethyl acrylate 
16         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
30         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
50         
 200 139 0.695 39.5 20 0.100 9.0 119 0.595 36.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 44 0.220 18.5 18 0.090 8.0 26 0.130 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 35 0.700 44.0 9 0.180 18.0 16 0.320 28.0 10 0.200 1.0
Trend: 11.199 4.712 11.080  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/02/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 6 0.030 1.5 1 0.005 0.5 5 0.025 1.0 0 0.000 0.0
Test Chemical: Ethyl acrylate 
50         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
100         
 200 6 0.030 2.5 0 0.000 0.0 6 0.030 2.5 0 0.000 0.0 
160         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 24 0.120 12.0 7 0.035 3.5 17 0.085 8.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 14 0.280 24.0 9 0.180 16.0 5 0.100 8.0 0 0.000 0.0
Trend: 0.042 -1.356 0.397  
Probability: 0.483 0.912 0.346  


Trial #:2   Activation: No Activation    Date: 04/22/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ethyl acrylate 
10         
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0 
16         
 200 8 0.040 4.0 0 0.000 0.0 8 0.040 4.0 0 0.000 0.0 
30         
 200 12 0.060 6.0 0 0.000 0.0 12 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 51 0.255 21.0 17 0.085 8.0 34 0.170 15.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 18 0.360 36.0 8 0.160 16.0 10 0.200 20.0 0 0.000 0.0
Trend: 2.938 0.000 2.938  
Probability: 0.002 0.000 0.002