Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02137-0015-0000-1
Chemical Name:	Ethyl acrylate
CASRN:	140-88-5
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	270996
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	107	107	83	26	33
			96	103	119	41
			99	93	109	37
			95	96	85	30
Test Chemical	Ethyl acrylate	2.5	85	76	94	37	34
			93	86	89	32	34
		5	95	51	90	31	29
			98	59	77	26	29
		10	89	85	93	35	34
			91	94	88	32	34
		20	64	57	148	77	73*
			75	67	154	68	73*
		40

Positive Control	Methyl Methane Sulfonate	15	44	37	221	167	170*
			49	32	255	172	170*
	Methyl Methane Sulfonate	250	90	77	567	211	209*
			89	79	550	207	209*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	58	40	107	61	37
			95	112	81	29
			96	122	72	25
			91	126	92	34
Test Chemical	Ethyl acrylate	20	66	96	62	31	34
			83	94	91	37	34
		25	73	92	91	42	40
			77	91	90	39	40
		30	66	82	71	36	38
			61	85	74	40	38
		35	53	57	85	54	51
			72	63	103	48	51
		40	65	37	156	81	97*
			48	32	164	113	97*
Positive Control	Methyl Methane Sulfonate	20	36	15	244	225	220*
			30	15	194	214	220*
	Methyl Methane Sulfonate	250	75	59	418	185	179*
			75	70	392	173	179*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination