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Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0017-0000-3
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 272157_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/14/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1628
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 13.00 ± 3.36 0.0000
Test Chemical Ethyl acrylate 
275         
 8 3.25 ± 1.25 0.5000
  
550         
 8 2.50 ± 0.50 0.7372
  
1100         
 8 4.50 ± 0.98 0.1798
Vehicle Control No Stressor 
 0         
 8 3.25 ± 1.06 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/05/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.7175
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 20.75 ± 4.32 0.0000
Test Chemical Ethyl acrylate 
225         
 8 2.75 ± 0.92 0.3253
  
450         
 8 3.00 ± 1.20 0.2535
  
900         
 8 1.75 ± 0.96 0.6932
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed