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Study Information
Study Attribute Value
CEBS Accession Number: 002-02147-0001-0000-7
Chemical Name: Ethyl methacrylate
CASRN: 97-63-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 636687_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/14/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 499 0.477 9.98 26.0 0.000
Test Chemical Ethyl methacrylate 
50         
 50 1045 434 0.415 8.68 26.0 -12.943 
160         
 50 1044 442 0.423 8.84 26.0 -11.253 
500         
 50 1048 478 0.456 9.56 26.0 -4.391 
1600         
 50 1047 487 0.465 9.74 26.0 -2.498
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 630 0.602 12.60 26.0 26.132
Mitomycin-C 
 0.005     
 10 210 442 2.105 44.20 26.0 341.199
Trend: 0.256        
Probability: 0.399        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/14/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 426 0.408 8.52 26.0 0.000
Test Chemical Ethyl methacrylate 
50         
 50 1046 433 0.414 8.66 26.0 1.449 
160         
 50 1046 441 0.422 8.82 26.0 3.323 
500         
 50 1047 484 0.462 9.68 26.0 13.289 
1600         
 50 1050 563 0.536 11.26 26.0 31.404
Positive Control Cyclophosphamide 
 0.15      
 50 1046 695 0.664 13.90 26.0 62.834
Cyclophosphamide 
 0.6       
 10 210 224 1.067 22.40 26.0 161.408
Trend: 4.657        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/08/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 503 0.479 10.06 26.0 0.000
Test Chemical Ethyl methacrylate 
1000         
 50 1049 571 0.544 11.42 26.0 13.627 
1600         
 50 1049 641 0.611 12.82 26.0 27.557 
3000         
 50 1050 724 0.690 14.48 26.0 43.936 
4000         
 50 1049 832 0.793 16.64 31.0 65.565 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.15      
 50 1049 620 0.591 12.40 26.0 23.378
Cyclophosphamide 
 0.6       
 10 210 235 1.119 23.50 26.5 133.598
Trend: 9.944        
Probability: 0.000