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Study Information
Study Attribute Value
CEBS Accession Number: 002-02147-0002-0000-8
Chemical Name: Ethyl methacrylate
CASRN: 97-63-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 636687_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/27/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ethyl methacrylate 
1000         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
1600         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0 
3000         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 46 0.230 21.0 17 0.085 8.0 29 0.145 14.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 24 0.480 34.0 7 0.140 10.0 17 0.340 28.0 0 0.000 0.0
Trend: 2.181 0.000 2.181  
Probability: 0.015 0.000 0.015  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/16/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Ethyl methacrylate 
1000         
 200 3 0.015 2.0 1 0.005 1.0 2 0.010 1.0 0 0.000 0.0 
1600         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0 
3000         
 200 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0 0 0.000 0.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 53 0.265 20.0 15 0.075 6.0 38 0.190 17.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 26 0.520 42.0 6 0.120 12.0 20 0.400 34.0 0 0.000 0.0
Trend: -0.045 0.970 -0.742  
Probability: 0.518 0.166 0.771