Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02147-0002-0000-8 |
Chemical Name: | Ethyl methacrylate |
CASRN: | 97-63-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 636687_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ethyl methacrylate | 1000 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
1600 | 200 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | ||
3000 | 200 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 | 200 | 46 | 0.230 | 21.0 | 17 | 0.085 | 8.0 | 29 | 0.145 | 14.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 24 | 0.480 | 34.0 | 7 | 0.140 | 10.0 | 17 | 0.340 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | 2.181 | 0.000 | 2.181 | ||||||||||||
Probability: | 0.015 | 0.000 | 0.015 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ethyl methacrylate | 1000 | 200 | 3 | 0.015 | 2.0 | 1 | 0.005 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
1600 | 200 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | ||
3000 | 200 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 53 | 0.265 | 20.0 | 15 | 0.075 | 6.0 | 38 | 0.190 | 17.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 26 | 0.520 | 42.0 | 6 | 0.120 | 12.0 | 20 | 0.400 | 34.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.045 | 0.970 | -0.742 | ||||||||||||
Probability: | 0.518 | 0.166 | 0.771 |