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Study Information
Study Attribute Value
CEBS Accession Number: 002-02148-0001-0000-8
Chemical Name: Ethyl methanesulfonate
CASRN: 62-50-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 975642_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/22/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 364 0.348 7.28 25.8 0.000
Test Chemical Ethyl methanesulfonate 
16.8       
 50 1046 808 0.772 16.16 25.8 122.190 
50.4       
 25 524 540 1.031 21.60 25.8 196.420 
168         
 5 104 217 2.087 43.40 25.8 500.166 
503.9       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1040 603 0.580 12.06 25.8 66.774
Mitomycin-C 
 0.01      
 5 105 217 2.067 43.40 25.8 494.451
Trend: 22.516        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/26/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 377 0.360 7.54 25.9 0.000
Test Chemical Ethyl methanesulfonate 
124.9       
 10 206 464 2.252 46.40 25.9 524.944 
249.8       
 5 103 350 3.398 70.00 31.2 842.803 
372.9       
 5 102 388 3.804 77.60 31.2 955.412 
503.9       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 654 0.623 13.08 25.9 72.814
Mitomycin-C 
 0.01      
 5 105 225 2.143 45.00 25.9 494.543
Trend: 43.094        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/22/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 436 0.415 8.72 25.8 0.000
Test Chemical Ethyl methanesulfonate 
168         
 50 1048 925 0.883 18.50 25.8 112.763 
503.9       
 10 210 288 1.371 28.80 25.8 230.590 
1679.6       
 5 101 368 3.644 73.60 25.8 778.300 
5038.9       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1050 502 0.478 10.04 25.8 15.247
Cyclophosphamide 
2         
 5 105 149 1.419 29.80 25.8 242.069
Trend: 31.907        
Probability: 0.000