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Study Information
Study Attribute Value
CEBS Accession Number: 002-02148-0002-0000-9
Chemical Name: Ethyl methanesulfonate
CASRN: 62-50-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 975642_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 06/18/1987    Harvest Time: 20.4 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 7 0.035 2.5 2 0.010 1.0 5 0.025 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ethyl methanesulfonate 
301.8       
 200 64 0.320 22.0 33 0.165 14.0 31 0.155 12.5 0 0.000 0.0 
754.6       
 10 23 2.300 100.0 15 1.500 90.0 8 0.800 60.0 0 0.000 0.0 
1509.2       
 10 83 8.300 100.0 15 1.500 40.0 8 0.800 30.0 60 6.000 60.0 
2252.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 45 0.225 17.0 18 0.090 9.0 27 0.135 11.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 13 0.520 32.0 9 0.360 28.0 4 0.160 12.0 0 0.000 0.0
Trend: 11.692 8.471 7.161  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/11/1987    Harvest Time: 20.7 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 1.5 2 0.010 1.0 2 0.010 0.5 0 0.000 0.0
Test Chemical: Ethyl methanesulfonate 
2515.2       
 10 18 1.800 80.0 11 1.100 60.0 7 0.700 40.0 0 0.000 0.0 
3754.1       
 10 92 9.200 100.0 12 1.200 30.0 10 1.000 30.0 70 7.000 70.0 
5005.5       
 10 93 9.300 100.0 3 0.300 10.0 0 0.000 0.0 90 9.000 90.0
Positive Control: Cyclophosphamide 
6.25      
 200 32 0.160 15.5 6 0.030 3.0 26 0.130 13.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 15 0.600 44.0 6 0.240 24.0 9 0.360 32.0 0 0.000 0.0
Trend: 13.168 4.836 3.991  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 06/25/1987    Harvest Time: 20.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ethyl methanesulfonate 
1250         
 10 56 5.600 100.0 21 2.100 90.0 25 2.500 80.0 10 1.000 10.0 
1500         
 10 93 9.300 100.0 5 0.500 20.0 8 0.800 20.0 80 8.000 80.0 
1750         
 10 98 9.800 100.0 1 0.100 10.0 7 0.700 10.0 90 9.000 90.0 
2000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 13 0.130 11.0 4 0.040 4.0 9 0.090 7.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 20 0.800 60.0 8 0.320 32.0 12 0.480 36.0 0 0.000 0.0
Trend: 10.296 3.287 3.254  
Probability: 0.000 0.001 0.001