Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02150-0010-0000-1
Chemical Name:	Ethyl tellurac
CASRN:	20941-65-5
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	326120
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	141r	133	209	49	65
			104	98	181	58
			150r	114	248	55
			87	102	185	71
Test Chemical	Ethyl tellurac	1.25	101	94	143	47	49
			93	79	152	55
			108	94	143	44
		2.5	99	90	138	47	47
			83	96	124	50
			102	101	136	44
		5	115#	89	241	70	80
			101	90	269	89
			138r	123	161	39
		10	100	77	163	54	66
			73	77	173	79
			93	80	181	65
		20	105	44	191	61	70
			56	22	125	75
			69	21	156	76
		30	73	14	238	108	134*
			65	11	262	135
			61	6	289	157
		40


Positive Control	Ethyl Methane Sulfonate	250	84#	55	1023	405	389*
			95	65	1071	377
			92	69	1063	384

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	91	92	158	58	62
			94	98	162	58
			89	116	188	70
			92	94	174	63
Test Chemical	Ethyl tellurac	2.5	90#	71	135	50	56
			75	93	150	67
			99	107	150	51
		5	89	103	174	65	56
			73	103	126	58
			75	100	100	45
		10	84	100	253	100	79
			89	110	159	59
			103	111	236	76
		20	75	52	148	66	58
			89	64	144	54
			108	71	172	53
		30	71	28	239	112	96*
			84	29	216	86
			58	27	158	91
		40	62#	16	222	120	106*
			81	13	247	101
			82	14	239	98
Positive Control	Ethyl Methane Sulfonate	250	65	49	998	510	449*
			76	56	951	415
			75	49	949	421

Induced S9 Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	267r	305	180	22	71
			74#	93	197	89
			98	89	182	62
			115	118	216	63
Test Chemical	Ethyl tellurac	0.313	84	77	203	80	81
			75	80	177	78
			80	105	199	83
		0.625	83	89	218	88	80
			94	86	222	78
			103	110	232	75
		1.25	91#	89	192	70	89
			78#	63	227	97
			94	69	279	99
		2.5	62#	41	303	164	179*
			71	28	447	210
			73	52	359	165
		5	78	26	403	171	196*
			70	17	394	189
			59	14	404	228
		10	63#	3	412.5	219	165*
			69	4	276	133
			63	8	274	145
Positive Control	3-Methylcholanthrene	2.5	67	42	866	429	410*
			73	58	844	387
			61	61	760	413

Induced S9 Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	99#	127	79	27	34
			86	94	84	32
			86	107	102	39
			75	72	80	36
Test Chemical	Ethyl tellurac	2.5	75#	54	102	45	45
			87	69	112	43
			76	63	108	47
		5	106	35	173	54	57*
			72	35	156	72
			79#	50	103	43
		7.5	70	28	186	88	81*
			63	27	162	86
			95	32	195	68
		10	79	31	194	82	91*
			67	22	170	85
			67	21	214	107
		15	82	19	244	99	111*
			81	10	266	109
			63	14	235	124
Positive Control	3-Methylcholanthrene	2.5	93	54	498	179	190*
			90	72	544	203
			83	77	469	188

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination