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Study Information
Study Attribute Value
CEBS Accession Number: 002-02153-0001-0000-4
Chemical Name: Ethyl-3-methyl-3-phenylglycidate
CASRN: 77-83-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 982566_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/20/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 430 0.411 8.60 26.0 0.000
Test Chemical Ethyl-3-methyl-3-phenylglycidate 
16         
 50 1046 543 0.519 10.86 26.0 26.400 
50         
 50 1049 664 0.633 13.28 26.0 54.124 
160         
 25 522 649 1.243 25.96 26.0 202.728
Positive Control Mitomycin-C 
 0.005     
 50 1054 900 0.854 18.00 26.0 107.912
Trend: 17.894        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/20/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 482 0.461 9.64 26.0 0.000
Test Chemical Ethyl-3-methyl-3-phenylglycidate 
16         
 50 1046 503 0.481 10.06 26.0 4.257 
50         
 50 1049 535 0.510 10.70 26.0 10.573 
160         
 50 1046 519 0.496 10.38 26.0 7.573 
500         
 50 1049 563 0.537 11.26 26.0 16.360
Positive Control Cyclophosphamide 
1         
 25 523 487 0.931 19.48 26.0 101.882
Trend: 2.410        
Probability: 0.008