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Study Information
Study Attribute Value
CEBS Accession Number: 002-02153-0002-0000-5
Chemical Name: Ethyl-3-methyl-3-phenylglycidate
CASRN: 77-83-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 982566_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 10/20/1982    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ethyl-3-methyl-3-phenylglycidate 
50         
 100 8 0.080 8.0 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 
160         
 100 6 0.060 4.0 1 0.010 1.0 5 0.050 4.0 0 0.000 0.0 
500         
 100 10 0.100 8.0 1 0.010 1.0 9 0.090 7.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 24 0.480 34.0 8 0.160 14.0 16 0.320 26.0 0 0.000 0.0
Trend: 1.700 -0.514 2.470  
Probability: 0.045 0.696 0.007  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/20/1982    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Ethyl-3-methyl-3-phenylglycidate 
50         
 100 9 0.090 9.0 2 0.020 2.0 7 0.070 7.0 0 0.000 0.0 
160         
 100 10 0.100 9.0 2 0.020 2.0 8 0.080 7.0 0 0.000 0.0 
500         
 100 14 0.140 12.0 2 0.020 2.0 12 0.120 10.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 17 0.340 26.0 7 0.140 14.0 10 0.200 18.0 0 0.000 0.0
Trend: 1.923 0.512 1.870  
Probability: 0.027 0.304 0.031