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Study Information
Study Attribute Value
CEBS Accession Number: 002-02154-0001-0000-5
Chemical Name: Ethylbenzene
CASRN: 100-41-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 228892_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Test Failure 
Induced Rat Liver S9  3_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/29/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 498 0.477 9.96 26.3 0.000
Test Chemical Ethylbenzene 
90.4       
 50 1045 480 0.459 9.60 26.3 -3.799 
301         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1041 749 0.720 14.98 26.3 50.691
Mitomycin-C 
 0.01      
 5 105 201 1.914 40.20 26.3 300.924
Trend: -0.606        
Probability: 0.728        

Trial #: 2    Activation: No Activation    Date: 04/21/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 555 0.531 11.10 25.5 0.000
Test Chemical Ethylbenzene 
75.5       
 50 1046 551 0.527 11.02 25.5 -0.816 
99.5       
 50 1049 522 0.498 10.44 25.5 -6.305 
125         
 50 1033 590 0.571 11.80 25.5 7.541 
151         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1041 773 0.743 15.46 25.5 39.814
Mitomycin-C 
 0.01      
 5 103 220 2.136 44.00 25.5 302.169
Trend: 0.837        
Probability: 0.201        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/29/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 443 0.426 8.86 26.3 0.000
Test Chemical Ethylbenzene 
90.4       
 50 1048 509 0.486 10.18 26.3 14.131 
301         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1047 608 0.581 12.16 26.3 36.460
Cyclophosphamide 
2         
 5 106 185 1.745 37.00 26.3 310.122
Trend: 2.036        
Probability: 0.021        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/19/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 593 0.572 11.86 25.5 0.000
Test Chemical Ethylbenzene 
75.5       
 50 1039 666 0.641 13.32 25.5 11.986 
99.5       
 50 1047 642 0.613 12.84 25.5 7.126 
125         
 50 1045 661 0.633 13.22 25.5 10.507 
151         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1055 609 0.577 12.18 25.5 0.849
Cyclophosphamide 
2         
 5 105 199 1.895 39.80 25.5 231.107
Trend: 1.353        
Probability: 0.088        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 09/07/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 531 0.507 10.62 25.8 0.000
Test Chemical Ethylbenzene 
125         
 50 1044 561 0.537 11.22 25.8 5.953 
137.5       
 50 1041 531 0.510 10.62 25.8 0.576 
150         
 50 1037 516 0.498 10.32 25.8 -1.888 
175         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1048 723 0.690 14.46 25.8 36.028
Cyclophosphamide 
2         
 5 108 159 1.472 31.80 25.8 190.286
Trend: -0.499        
Probability: 0.691