Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02154-0013-0000-8
Chemical Name:	Ethylbenzene
CASRN:	100-41-4
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	746837
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	87	92	138	53	60
			78	108	155	66
			89	106	150	56
			84	94	159	63
Test Chemical	Ethylbenzene	10	86	106	157	61	56
			81	103	123	51	56
		20	81	90	130	54	53
			81	93	127	52	53
		40	73	72	144	66	67
			87	82	175	67	67
		80	71	32	1325	619	589*
			74	36	1235	559	589*
		160

Positive Control	Methyl Methane Sulfonate	15	52	39	238	152	145*
			61	40	251	138	145*
	Methyl Methane Sulfonate	250	83	95	374	150	149*
			81	85	357	147	149*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	100	101	91	30	31
			82	98	75	30
			69	95	63	30
			85	106	87	34
Test Chemical	Ethylbenzene	20	82	83	102	41	43
			83	83	109	44	43
		40	73	54	58	27	29
			78	61	75	32	29
		60	68	60	79	39	43
			64	37	91	48	43
		80	55	15	233	142	150*
			48	10	228	159	150*
		100

Positive Control	Methyl Methane Sulfonate	15	42	32	152	120	107*
			43	34	122	94	107*
	Methyl Methane Sulfonate	250	50	67	302	201	225*
			51	67	381	250	225*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination