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Study Information
Study Attribute Value
CEBS Accession Number: 002-02158-0001-0000-9
Chemical Name: Ethylene glycol
CASRN: 107-21-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 706666_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/05/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 404 0.386 8.08 27.5 0.000
Negative (Not Specified) 
0         
 50 1043 379 0.363 7.58 27.5 -5.918
Test Chemical Ethylene glycol 
160         
 50 1041 400 0.384 8.00 27.5 -0.515 
500         
 50 1041 388 0.373 7.76 27.5 -3.499 
1600         
 50 1047 419 0.400 8.38 27.5 3.614 
5000         
 50 1040 436 0.419 8.72 27.5 8.543
Positive Control Mitomycin-C 
 0.005     
 50 1045 539 0.516 10.78 27.5 33.544
Mitomycin-C 
 0.01      
 10 208 164 0.788 16.40 27.5 104.141
Trend: 1.336        
Probability: 0.091        

Trial #: 2    Activation: No Activation    Date: 08/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 425 0.406 8.50 26.5 0.000
Test Chemical Ethylene glycol 
1600         
 50 1050 420 0.400 8.40 26.5 -1.365 
3000         
 50 1048 395 0.377 7.90 26.5 -7.059 
4000         
 50 1049 431 0.411 8.62 26.5 1.315 
5000         
 50 1048 423 0.404 8.46 26.5 -0.471
Positive Control Mitomycin-C 
 0.0E-4    
 50 1052 644 0.612 12.88 26.5 50.953
Mitomycin-C 
 0.01      
 10 210 580 2.762 58.00 26.5 581.053
Trend: -0.045        
Probability: 0.518        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/05/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 418 0.399 8.36 26.0 0.000
Negative (Not Specified) 
0         
 50 1043 444 0.426 8.88 26.0 6.627
Test Chemical Ethylene glycol 
160         
 50 1046 450 0.430 9.00 26.0 7.758 
500         
 50 1045 430 0.411 8.60 26.0 3.068 
1600         
 50 1048 435 0.415 8.70 26.0 3.968 
5000         
 50 1048 478 0.456 9.56 26.0 14.245
Positive Control Cyclophosphamide 
 0.3       
 50 1044 607 0.581 12.14 26.0 45.633
Cyclophosphamide 
2         
 10 210 381 1.814 38.10 26.0 354.440
Trend: 1.552        
Probability: 0.060        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 416 0.398 8.32 26.0 0.000
Test Chemical Ethylene glycol 
1600         
 50 1048 430 0.410 8.60 26.0 3.168 
3000         
 50 1048 409 0.390 8.18 26.0 -1.870 
4000         
 50 1050 427 0.407 8.54 26.0 2.253 
5000         
 50 1050 435 0.414 8.70 26.0 4.169
Positive Control Cyclophosphamide 
 0.3       
 50 1050 605 0.576 12.10 26.0 44.879
Cyclophosphamide 
2         
 10 209 414 1.981 41.40 26.0 398.072
Trend: 0.332        
Probability: 0.370