Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02158-0010-0000-9 |
Chemical Name: | Ethylene glycol |
CASRN: | 107-21-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 062928 |
Study Result: | Negative |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 102 | 111 | 146 | 48 | 60 |
84 | 113 | 154 | 61 | ||||
105 | 99 | 194 | 61 | ||||
62 | 77 | 129 | 70 | ||||
Test Chemical | Ethylene glycol | 312.5 | 60 | 95 | 589 | 326 | 274* |
81 | 119 | 536 | 221 | ||||
625 | 93 | 107 | 379 | 136 | 153* | ||
100 | 108 | 512 | 170 | ||||
1250 | 79 | 99 | 390 | 166 | 221* | ||
53# | 62 | 443 | 277 | ||||
2500 | 65 | 97 | 282 | 145 | 156* | ||
74 | 112 | 374 | 168 | ||||
5000 | 78 | 109 | 200 | 85 | 113* | ||
64 | 93 | 270 | 141 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 31 | 18 | 826 | 883 | 1167* |
24 | 9 | 1022 | 1450 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 98 | 102 | 129 | 44 | 43 |
88 | 91 | 101 | 38 | ||||
91 | 102 | 114 | 42 | ||||
78 | 105 | 111 | 48 | ||||
Test Chemical | Ethylene glycol | 1000 | 76 | 92 | 127 | 56 | 49 |
79 | 73 | 100 | 42 | ||||
96 | 119 | 144 | 50 | ||||
2000 | 89 | 97 | 103 | 39 | 45 | ||
70 | 75 | 115 | 55 | ||||
62 | 94 | 76 | 41 | ||||
3000 | 100 | 103 | 147 | 49 | 53 | ||
75 | 72 | 118 | 52 | ||||
69 | 89 | 119 | 58 | ||||
4000 | 68 | 93 | 138 | 68 | 63* | ||
72 | 93 | 143 | 66 | ||||
75 | 106 | 125 | 55 | ||||
5000 | 101 | 96 | 130 | 43 | 49 | ||
81 | 103 | 122 | 50 | ||||
83 | 72 | 134 | 54 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 28 | 21 | 264 | 312 | 304* |
27 | 15 | 241 | 296 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 49r | 91 | 64 | 43 | 51 |
55 | 85 | 91 | 55 | ||||
66 | 102 | 102 | 52 | ||||
56 | 112 | 75 | 45 | ||||
Test Chemical | Ethylene glycol | 2000 | 42 | 81 | 92 | 73 | 69 |
52 | 91 | 103 | 65 | ||||
3000 | 37 | 107 | 100 | 90 | 81 | ||
44 | 92 | 94 | 71 | ||||
4000 | 41 | 100 | 132 | 108 | 101* | ||
50 | 95 | 141 | 95 | ||||
5000 | 39 | 79 | 115 | 98 | 100* | ||
46 | 101 | 141 | 103 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 20 | 19 | 163 | 269 | 240* |
27 | 25 | 171 | 211 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 84 | 102 | 142 | 56 | 46 |
79 | 98 | 86 | 36 | ||||
79 | 99 | 112 | 47 | ||||
99 | 101 | 134 | 45 | ||||
Test Chemical | Ethylene glycol | 1000 | 96 | 107 | 124 | 43 | 42 |
105 | 116 | 127 | 40 | ||||
2000 | 73 | 89 | 120 | 55 | 51 | ||
76 | 94 | 105 | 46 | ||||
3000 | 65 | 85 | 124 | 63 | 62 | ||
76 | 86 | 138 | 61 | ||||
4000 | 57 | 65 | 96 | 56 | 66 | ||
71 | 79 | 161 | 76 | ||||
5000 | 63 | 79 | 97 | 52 | 47 | ||
66 | 79 | 82 | 42 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 43 | 23 | 254 | 198 | 188* |
38 | 27 | 204 | 179 | ||||
Methyl Methane Sulfonate | 250 | 56 | 64 | 481 | 288 | 311* | |
49 | 62 | 487 | 334 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 89 | 88 | 70 | 26 | 30 |
88 | 103 | 78 | 30 | ||||
83 | 104 | 91 | 37 | ||||
91 | 104 | 79 | 29 | ||||
Test Chemical | Ethylene glycol | 1000 | 84 | 113 | 71 | 28 | 29 |
82 | 93 | 71 | 29 | ||||
2000 | 93 | 97 | 79 | 28 | 26 | ||
86 | 92 | 63 | 24 | ||||
3000 | 81 | 90 | 80 | 33 | 34 | ||
68 | 93 | 72 | 35 | ||||
4000 | 77 | 93 | 78 | 34 | 32 | ||
70 | 98 | 65 | 31 | ||||
5000 | 81 | 109 | 79 | 33 | 27 | ||
77 | 111 | 47 | 20 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 49 | 30 | 418 | 283 | 271* |
52 | 34 | 403 | 259 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 64 | 97 | 96 | 50 | 54 |
71 | 107 | 146 | 69 | ||||
71 | 84 | 118 | 56 | ||||
66 | 112 | 86 | 43 | ||||
Test Chemical | Ethylene glycol | 1000 | 69 | 91 | 146 | 71 | 74 |
69 | 98 | 161 | 78 | ||||
2000 | 66 | 95 | 142 | 72 | 74 | ||
62 | 73 | 143 | 76 | ||||
3000 | 67 | 100 | 133 | 66 | 64 | ||
55 | 93 | 101 | 61 | ||||
4000 | 71 | 88 | 147 | 69 | 73 | ||
74 | 99 | 174 | 78 | ||||
5000 | 73 | 111 | 140 | 64 | 75 | ||
78 | 94 | 198 | 85 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 44 | 29 | 558 | 424 | 407* |
39 | 22 | 455 | 391 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination