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Study Information
Study Attribute Value
CEBS Accession Number: 002-02161-0002-0000-4
Chemical Name: Ethylene glycol monoethyl ether (EGMEE)
CASRN: 110-80-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 032435_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/14/1981    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Medium 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Ethylene glycol monoethyl ether (EGMEE) 
4780         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 
6830         
 100 12 0.120 11.0 6 0.060 6.0 6 0.060 5.0 0 0.000 0.0 
9510         
 100 15 0.150 13.0 12 0.120 12.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.75      
 100 28 0.280 21.0 13 0.130 11.0 14 0.140 12.0 1 0.010 1.0
Trend: 3.546 3.521 1.683  
Probability: 0.000 0.000 0.046  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/14/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ethylene glycol monoethyl ether (EGMEE) 
4780         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
6830         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
9510         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 80 38 0.475 26.0 16 0.200 18.0 12 0.150 13.0 10 0.125 1.0
Trend: 0.000 -1.275 1.275  
Probability: 0.500 0.899 0.101