COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02165-0001-0000-7
Chemical Name: Ethylene thiourea (ETU)
CASRN: 96-45-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 007998_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/05/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 472 0.450 9.44 25.5 0.000
Test Chemical Ethylene thiourea (ETU) 
500         
 50 1036 476 0.459 9.52 25.5 2.113 
1667         
 50 1047 446 0.426 8.92 25.5 -5.328 
5000         
 50 1040 557 0.536 11.14 33.8 19.030
Positive Control Mitomycin-C 
 0.001     
 50 1044 655 0.627 13.10 25.5 39.436
Mitomycin-C 
 0.01      
 5 105 251 2.390 50.20 25.5 431.273
Trend: 2.301        
Probability: 0.011        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/05/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 509 0.487 10.18 25.5 0.000
Test Chemical Ethylene thiourea (ETU) 
500         
 50 1040 474 0.456 9.48 25.5 -6.429 
1667         
 50 1037 460 0.444 9.20 25.5 -8.930 
5000         
 50 1039 422 0.406 8.44 25.5 -16.614
Positive Control Cyclophosphamide 
 0.35      
 50 1044 716 0.686 14.32 25.5 40.803
Cyclophosphamide 
2         
 5 103 174 1.689 34.80 25.5 246.825
Trend: -2.740        
Probability: 0.997        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/02/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 569 0.544 11.38 25.5 0.000
Test Chemical Ethylene thiourea (ETU) 
8000         
 50 1048 617 0.589 12.34 25.5 8.229 
9000         
 50 1041 571 0.549 11.42 25.5 0.833 
10000         
 50 1043 593 0.569 11.86 25.5 4.518
Positive Control Cyclophosphamide 
 0.35      
 50 1042 853 0.819 17.06 25.5 50.488
Cyclophosphamide 
2         
 5 103 200 1.942 40.00 25.5 256.954
Trend: 0.306        
Probability: 0.380