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Study Information
Study Attribute Value
CEBS Accession Number: 002-02165-0002-0000-8
Chemical Name: Ethylene thiourea (ETU)
CASRN: 96-45-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 007998_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/16/1983    Harvest Time: 22.7 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 7 0.070 6.0 1 0.010 1.0 5 0.050 4.0 1 0.010 1.0
Test Chemical: Ethylene thiourea (ETU) 
6000         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0 
7000         
 100 4 0.040 3.0 0 0.000 0.0 3 0.030 2.0 1 0.010 1.0 
8000         
 100 7 0.070 7.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 
9000         
 100 11 0.110 9.0 3 0.030 3.0 6 0.060 4.0 2 0.020 2.0
Positive Control: Mitomycin-C 
 0.05      
 50 49 0.980 50.0 25 0.500 40.0 24 0.480 28.0 0 0.000 0.0
Trend: 1.331 1.649 0.362  
Probability: 0.092 0.050 0.359  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/23/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 4.0 0 0.000 0.0 3 0.030 2.0 2 0.020 2.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 1 0.010 1.0 2 0.020 2.0
Test Chemical: Ethylene thiourea (ETU) 
8000         
 100 5 0.050 5.0 2 0.020 2.0 1 0.010 1.0 2 0.020 2.0 
9000         
 100 8 0.080 7.0 1 0.010 1.0 4 0.040 4.0 3 0.030 3.0 
10000         
 100 8 0.080 8.0 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 50 21 0.420 30.0 11 0.220 20.0 9 0.180 14.0 1 0.020 2.0
Trend: 1.321 1.253 1.378  
Probability: 0.093 0.105 0.084