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Study Information
Study Attribute Value
CEBS Accession Number: 002-02170-0001-0000-3
Chemical Name: Eugenol
CASRN: 97-53-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 416109_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/25/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 483 0.465 9.66 25.7 0.000
Test Chemical Eugenol 
11         
 50 1038 513 0.494 10.26 25.7 6.211 
36         
 50 1037 545 0.526 10.90 25.7 12.945 
107         
 50 1029 585 0.569 11.70 31.5 22.177
Positive Control Mitomycin-C 
 0.005     
 25 522 774 1.483 30.96 25.7 218.655
Trend: 3.416        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/28/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 440 0.420 8.80 25.5 0.000
Test Chemical Eugenol 
75         
 50 1044 573 0.549 11.46 25.5 30.601 
99         
 50 1045 549 0.525 10.98 25.5 25.012 
123         
 50 1041 639 0.614 12.78 25.5 46.064 
150         
 0 0 0 0.000 0.00 34.3 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 609 0.581 12.18 25.5 38.145
Mitomycin-C 
 0.01      
 5 103 217 2.107 43.40 25.5 401.322
Trend: 5.439        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/25/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 470 0.449 9.40 25.7 0.000
Test Chemical Eugenol 
107         
 50 1038 536 0.516 10.72 25.7 14.921 
358         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 519 705 1.358 28.20 25.7 202.312
Trend: 2.203        
Probability: 0.014        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/25/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 420 0.401 8.40 25.5 0.000
Test Chemical Eugenol 
273         
 50 1048 577 0.551 11.54 25.5 37.250 
300         
 50 1044 550 0.527 11.00 34.3 31.329 
326         
 50 1046 606 0.579 12.12 34.3 44.424
Positive Control Cyclophosphamide 
 0.3       
 50 1046 669 0.640 13.38 25.5 59.438
Cyclophosphamide 
2         
 5 105 198 1.886 39.60 25.5 370.082
Trend: 5.134        
Probability: 0.000