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Study Information
Study Attribute Value
CEBS Accession Number: 002-02170-0002-0000-4
Chemical Name: Eugenol
CASRN: 97-53-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 416109_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 09/01/1982    Harvest Time: 24 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Eugenol 
198         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
251         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
300         
 25 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 100 32 0.320 32.0 16 0.160 26.0 6 0.060 8.0 10 0.100 1.0
Trend: 1.662 0.000 1.662  
Probability: 0.048 0.000 0.048  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/09/1982    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Eugenol 
201         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
251         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
300         
 100 10 0.100 8.0 2 0.020 2.0 8 0.080 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 50 8 0.160 16.0 2 0.040 4.0 5 0.100 10.0 1 0.020 2.0
Trend: 2.632 0.747 3.089  
Probability: 0.004 0.227 0.001  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/28/1982    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Eugenol 
274         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
299         
 100 4 0.040 3.0 4 0.040 3.0 0 0.000 0.0 0 0.000 0.0 
324         
 100 55 0.550 28.0 22 0.220 17.0 33 0.330 21.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 10 0.200 18.0 8 0.160 16.0 2 0.040 2.0 0 0.000 0.0
Trend: 7.211 5.499 6.245  
Probability: 0.000 0.000 0.000