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Study Information
Study Attribute Value
CEBS Accession Number: 002-02170-0013-0000-6
Chemical Name: Eugenol
CASRN: 97-53-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635999_CA
Study Result: Equivocal

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/29/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0001
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 9.50 ± 1.24 0.0000
Test Chemical Eugenol 
150         
 8 1.75 ± 0.59 0.2804
  
300         
 8 1.50 ± 0.82 0.3807
  
600         
 7 5.43 ± 1.21 0.0006
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/14/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.6107
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 14.25 ± 2.46 0.0000
Test Chemical Eugenol 
150         
 8 4.00 ± 0.65 0.0487
  
300         
 8 3.00 ± 1.00 0.1825
  
600         
 8 2.25 ± 0.45 0.4032
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/06/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.7049
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 9.25 ± 2.07 0.0000
Test Chemical Eugenol 
450         
 8 1.25 ± 0.75 0.7992
  
600         
 7 1.71 ± 0.29 0.6135
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.85 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed