COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02171-0001-0000-4
Chemical Name: FD & C yellow no. 6
CASRN: 2783-94-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 356840_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/01/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1036 379 0.366 7.58 25.5 0.000
Test Chemical FD & C yellow no. 6 
500         
 50 1021 409 0.401 8.18 25.5 9.501 
1666.7       
 50 1032 490 0.475 9.80 25.5 29.789 
5000         
 50 1033 472 0.457 9.44 25.5 24.900
Positive Control Mitomycin-C 
 0.001     
 50 1025 607 0.592 12.14 25.5 61.877
Mitomycin-C 
 0.01      
 5 104 192 1.846 38.40 25.5 404.648
Trend: 3.866        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/01/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 25 502 208 0.414 8.32 25.5 0.000
Test Chemical FD & C yellow no. 6 
3000         
 25 512 227 0.443 9.08 25.5 7.003 
4000         
 25 508 210 0.413 8.40 25.5 -0.231 
5000         
 25 506 224 0.443 8.96 25.5 6.841
Positive Control Mitomycin-C 
 0.001     
 25 506 272 0.538 10.88 25.5 29.735
Mitomycin-C 
 0.01      
 5 101 134 1.327 26.80 25.5 220.202
Trend: 0.384        
Probability: 0.350        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/01/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1009 415 0.411 8.30 25.5 0.000
Test Chemical FD & C yellow no. 6 
500         
 50 1008 392 0.389 7.84 25.5 -5.448 
1666.7       
 50 1033 364 0.352 7.28 25.5 -14.327 
5000         
 50 1022 426 0.417 8.52 25.5 1.345
Positive Control Cyclophosphamide 
 0.4       
 50 1031 638 0.619 12.76 25.5 50.454
Cyclophosphamide 
2         
 5 105 164 1.562 32.80 25.5 279.750
Trend: -0.266        
Probability: 0.605