Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02176-0002-0000-0 |
Chemical Name: | Fenthion |
CASRN: | 55-38-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 574321_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Questionable |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 |
Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Fenthion | 68.4 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 |
79.8 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
102.6 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | ||
136.8 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 50 | 17 | 0.340 | 30.0 | 14 | 0.280 | 26.0 | 2 | 0.040 | 4.0 | 1 | 0.020 | 2.0 |
Trend: | 0.784 | 0.000 | 0.311 | ||||||||||||
Probability: | 0.217 | 0.000 | 0.378 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Fenthion | 91.2 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 |
102.6 | 100 | 7 | 0.070 | 7.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 3.0 | 2 | 0.020 | 2.0 | ||
114 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | ||
136.8 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 10 | 50 | 15 | 0.300 | 24.0 | 12 | 0.240 | 22.0 | 3 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
Trend: | 0.986 | 0.079 | -0.131 | ||||||||||||
Probability: | 0.162 | 0.468 | 0.552 |