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Study Information
Study Attribute Value
CEBS Accession Number: 002-02178-0001-0000-1
Chemical Name: Ferrocene
CASRN: 102-54-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 203142_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/06/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 531 0.517 10.62 26.0 0.000
Negative (Not Specified) 
0         
 50 997 518 0.520 10.36 26.0 0.487
Test Chemical Ferrocene 
11         
 50 997 620 0.622 12.40 26.0 20.274 
33         
 50 1021 904 0.885 18.08 26.0 71.245 
110         
 50 1002 1162 1.160 23.24 34.0 124.292 
330         
 50 1012 1162 1.148 23.24 34.0 122.076
Positive Control Triethylenemelamine 
 0.015     
 50 1028 2084 2.027 41.68 26.0 292.085
Trend: 19.502        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/06/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1015 524 0.516 10.48 26.0 0.000
Negative (Not Specified) 
0         
 50 1021 526 0.515 10.52 26.0 -0.208
Test Chemical Ferrocene 
11         
 50 996 580 0.582 11.60 26.0 12.799 
33         
 50 986 596 0.604 11.92 26.0 17.086 
110         
 50 551 994 1.804 19.88 26.0 249.438 
330         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1028 1247 1.213 24.94 26.0 134.968
Cyclophosphamide 
2         
 50 1019 1560 1.531 31.20 26.0 196.541
Trend: 22.888        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/03/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1024 474 0.463 9.48 25.0 0.000
Test Chemical Ferrocene 
200         
 50 1034 615 0.595 12.30 25.0 28.492 
250         
 50 1035 652 0.630 13.04 25.0 36.091 
300         
 50 1034 663 0.641 13.26 25.0 38.521
Positive Control Cyclophosphamide 
1.5       
 50 1033 1215 1.176 24.30 25.0 154.096
Trend: 5.383        
Probability: 0.000