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Study Information
Study Attribute Value
CEBS Accession Number: 002-02178-0002-0000-2
Chemical Name: Ferrocene
CASRN: 102-54-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 203142_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/18/1981    Harvest Time: 22.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Ferrocene 
33         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
110         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
330         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 24 0.240 23.0 11 0.110 11.0 12 0.120 12.0 1 0.010 1.0
Trend: -1.090 -0.768 -0.768  
Probability: 0.862 0.779 0.779  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/18/1981    Harvest Time: 22.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ferrocene 
33         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
110         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
330         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 30 0.300 19.0 15 0.150 14.0 5 0.050 4.0 10 0.100 1.0
Trend: 0.152 -0.358 0.615  
Probability: 0.440 0.640 0.269  


Trial #:2   Activation: No Activation    Date: 12/29/1981    Harvest Time: 19 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 12 0.120 8.0 2 0.020 2.0 7 0.070 5.0 3 0.030 3.0
Dimethyl Sulfoxide 
0         
 100 8 0.080 6.0 4 0.040 4.0 4 0.040 2.0 0 0.000 0.0
Test Chemical: Ferrocene 
50         
 100 8 0.080 5.0 0 0.000 0.0 7 0.070 4.0 1 0.010 1.0 
301         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
402.5       
 100 2 0.020 1.0 0 0.000 0.0 2 0.020 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 25 132 5.280 92.0 20 0.800 44.0 12 0.480 32.0 100 4.000 52.0
Trend: -1.395 -1.110 -0.731  
Probability: 0.919 0.867 0.768  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 12/29/1981    Harvest Time: 19 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Ferrocene 
350         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
402.5       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 10 22 2.200 90.0 7 0.700 60.0 15 1.500 50.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.500 0.500 0.500