COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02178-0003-0000-3
Chemical Name: Ferrocene
CASRN: 102-54-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 674566_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/25/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 316 0.302 6.32 26.0 0.000
Test Chemical Ferrocene 
 0.4       
 50 1045 482 0.461 9.64 26.0 52.678 
1.3       
 50 1040 447 0.430 8.94 26.0 42.272 
4         
 50 1049 551 0.525 11.02 26.0 73.868
Positive Control Triethylenemelamine 
 0.015     
 50 1033 1456 1.409 29.12 26.0 366.558
Trend: 7.029        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/25/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 407 0.389 8.14 26.0 0.000
Test Chemical Ferrocene 
13         
 50 1045 526 0.503 10.52 26.0 29.238 
40         
 50 1046 614 0.587 12.28 26.0 50.716 
130         
 50 1045 567 0.543 11.34 26.0 39.312
Positive Control Cyclophosphamide 
1         
 50 1046 1486 1.421 29.72 26.0 264.762
Trend: 5.494        
Probability: 0.000