Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02178-0004-0000-4 |
Chemical Name: | Ferrocene |
CASRN: | 102-54-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 674566_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ferrocene | 40 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
130 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
400 | 100 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Triethylenemelamine | 0.15 | 100 | 32 | 0.320 | 26.0 | 14 | 0.140 | 14.0 | 18 | 0.180 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | 2.510 | 0.463 | 2.467 | ||||||||||||
Probability: | 0.006 | 0.322 | 0.007 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ferrocene | 40 | 100 | 10 | 0.100 | 8.0 | 1 | 0.010 | 1.0 | 9 | 0.090 | 8.0 | 0 | 0.000 | 0.0 |
130 | 100 | 12 | 0.120 | 9.0 | 4 | 0.040 | 4.0 | 8 | 0.080 | 7.0 | 0 | 0.000 | 0.0 | ||
400 | 100 | 11 | 0.110 | 10.0 | 2 | 0.020 | 2.0 | 9 | 0.090 | 8.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 72 | 0.720 | 40.0 | 30 | 0.300 | 26.0 | 42 | 0.420 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | 2.158 | 1.549 | 1.570 | ||||||||||||
Probability: | 0.015 | 0.061 | 0.058 |