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Study Information
Study Attribute Value
CEBS Accession Number: 002-02180-0001-0000-4
Chemical Name: Fluometuron
CASRN: 2164-17-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 054432_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Questionable 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/15/1986    Trial Call: Questionable   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1034 432 0.418 8.64 26.5 0.000
Test Chemical Fluometuron
8.45      
50 1036 420 0.405 8.40 26.5 -2.965
26.2       
50 1049 472 0.450 9.44 26.5 7.697
84.5       
50 1029 497 0.483 9.94 26.5 15.605
262         
0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C
 0.0015    
50 1024 640 0.625 12.80 26.5 49.595
Mitomycin-C
 0.01      
10 205 342 1.668 34.20 26.5 299.309
Trend: 2.605        
Probability: 0.005        

Trial #: 2    Activation: No Activation    Date: 10/30/1986    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1045 395 0.378 7.90 26.5 0.000
Test Chemical Fluometuron
79.5       
50 1041 490 0.471 9.80 26.5 24.527
99.5       
50 1048 455 0.434 9.10 26.5 14.860
150         
50 1049 498 0.475 9.96 26.5 25.595
199         
0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C
 0.0015    
50 1047 614 0.586 12.28 26.5 55.146
Mitomycin-C
 0.01      
10 211 262 1.242 26.20 26.5 228.502
Trend: 2.850        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/15/1986    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1048 427 0.407 8.54 25.5 0.000
Test Chemical Fluometuron
262         
50 1043 397 0.381 7.94 26.5 -6.580
845         
50 1049 363 0.346 7.26 26.5 -15.069
2620         
50 1049 441 0.420 8.82 26.5 3.180
Positive Control Cyclophosphamide
 0.5       
50 1046 719 0.687 14.38 25.5 68.706
Cyclophosphamide
2.5       
10 210 318 1.514 31.80 25.5 271.656
Trend: 0.033        
Probability: 0.487