Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02180-0001-0000-4 |
Chemical Name: | Fluometuron |
CASRN: | 2164-17-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 054432_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Questionable |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1034 | 432 | 0.418 | 8.64 | 26.5 | 0.000 |
Test Chemical | Fluometuron | 8.45 | 50 | 1036 | 420 | 0.405 | 8.40 | 26.5 | -2.965 |
26.2 | 50 | 1049 | 472 | 0.450 | 9.44 | 26.5 | 7.697 | ||
84.5 | 50 | 1029 | 497 | 0.483 | 9.94 | 26.5 | 15.605 | ||
262 | 0 | 0 | 0 | 0.000 | 0.00 | 30.5 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1024 | 640 | 0.625 | 12.80 | 26.5 | 49.595 |
Mitomycin-C | 0.01 | 10 | 205 | 342 | 1.668 | 34.20 | 26.5 | 299.309 | |
Trend: | 2.605 | ||||||||
Probability: | 0.005 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1045 | 395 | 0.378 | 7.90 | 26.5 | 0.000 |
Test Chemical | Fluometuron | 79.5 | 50 | 1041 | 490 | 0.471 | 9.80 | 26.5 | 24.527 |
99.5 | 50 | 1048 | 455 | 0.434 | 9.10 | 26.5 | 14.860 | ||
150 | 50 | 1049 | 498 | 0.475 | 9.96 | 26.5 | 25.595 | ||
199 | 0 | 0 | 0 | 0.000 | 0.00 | 26.5 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1047 | 614 | 0.586 | 12.28 | 26.5 | 55.146 |
Mitomycin-C | 0.01 | 10 | 211 | 262 | 1.242 | 26.20 | 26.5 | 228.502 | |
Trend: | 2.850 | ||||||||
Probability: | 0.002 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1048 | 427 | 0.407 | 8.54 | 25.5 | 0.000 |
Test Chemical | Fluometuron | 262 | 50 | 1043 | 397 | 0.381 | 7.94 | 26.5 | -6.580 |
845 | 50 | 1049 | 363 | 0.346 | 7.26 | 26.5 | -15.069 | ||
2620 | 50 | 1049 | 441 | 0.420 | 8.82 | 26.5 | 3.180 | ||
Positive Control | Cyclophosphamide | 0.5 | 50 | 1046 | 719 | 0.687 | 14.38 | 25.5 | 68.706 |
Cyclophosphamide | 2.5 | 10 | 210 | 318 | 1.514 | 31.80 | 25.5 | 271.656 | |
Trend: | 0.033 | ||||||||
Probability: | 0.487 |